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  1. Efecto de la nicotinamida como inhibidor de la poli (ADP-ribosa) polimerasa en cáncer de mama deficiente de BRCA1

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    Descrizione: Introduction: The nuclear enzyme poly (ADP-ribose) polymerase-1 (PARP-1) is essential for the repair of single-strand breaks in DNA by means of base excision repair and represents an important target in the therapy cancer. Inhibitors of PARP-1 have been shown to potentiate the cytotoxic effects of ionizing radiation and chemotherapeutic agents...
    Soggetto: Enzimas, Breast -- Cancer, Enzymes, NAD-ADP-ribosyltransferase, Biología experimental, Biology, Experimental, Poli ADP ribosa polimerasa, and Mamas -- Cáncer
    Creatore: Domínguez Gómez, María Guadalupe Isabel
    Collaboratore: García López, Patricia, Damián Matzumura, Pablo Gustavo, Gutiérrez Ruiz, María Concepción, Dueñas González, Alfonso, Gómez Quiroz, Luis Enrique, and Aréchaga Ocampo, Elena
    Editore: Universidad Autónoma Metropolitana
    Posgrado: Doctorado en Biologia Experimental
    Lingua: spa
    Año de publicación: 2014
    Diritti: Acceso Abierto
    Licenza: Atribucion-NoComercial 4.0 Internacional (CC BY-NC 4.0)
    Tipo de Recurso: Tesis de Doctorado
    Identifier: https://doi.org/10.24275/uami.wp988j98c